Sphingosine Forms Channels in Membranes That Differ Greatly from Those Formed by Ceramide
نویسندگان
چکیده
منابع مشابه
Sphingosine forms channels in membranes that differ greatly from those formed by ceramide.
Ceramide channels formed in the outer membrane of mitochondria have been proposed to be the pathways by which proapoptotic proteins are released from mitochondria during the early stages of apoptosis. We report that sphingosine also forms channels in membranes, but these differ greatly from the large oligomeric barrel-stave channels formed by ceramide. Sphingosine channels have short open lifet...
متن کاملCeramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations.
Recent evidence suggests that the ability of ceramides to induce apoptosis is due to a direct action on mitochondria. Mitochondria are known to contain enzymes responsible for ceramide synthesis and hydrolysis and mitochondrial ceramide levels have been shown to be elevated prior to the mitochondrial phase of apoptosis. Ceramides have been reported to induce the release of intermembrane space p...
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Ceramides are known to have a regulatory function in apoptosis, including the release of cytochrome c and other proapoptotic factors from the mitochondrial intermembrane space. Ceramides can form large, stable channels in the outer mitochondrial membrane, leading to the proposal that ceramide channels are the pathway through which these proteins are released. Here, we report that sphingosine, a...
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ژورنال
عنوان ژورنال: Journal of Bioenergetics and Biomembranes
سال: 2005
ISSN: 0145-479X,1573-6881
DOI: 10.1007/s10863-005-6632-2